Innovation Partner Roundtable – Targeting the Root, Not Just the Rhythm: Next-Generation Strategies for PKP2-ACM – Powered by Lexeo

September 05, 2025 | 09:45 AM (EDT) - 10:30 AM (EDT)

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Speakers

Dominic Abrams

Co-Director of the Center for Cardiovascular Genetics

Boston Children’s Hospital

Mina K. Chung

Staff Cardiologist & Professor of Medicine in the Section of Pacing and Electrophysiology

Cleveland Clinic

David Duncker, MD, FHRS

Head of Hannover Heart Rhythm Center

Hannover Medical School

Faisal Merchant

Director of Cardiac Electrophysiology and Associate Professor of Medicine

Emory Healthcare

Harikrishna Tandri

Professor of Medicine; Chief of Electrophsyiology

Vanderbilt University Medical Center

Moderator

Andrew Krahn

Professor of Medicine

University of British Columbia

Innovation Partner Roundtable - Targeting the Root, Not Just the Rhythm: Next-Generation Strategies for PKP2-ACM - Powered by Lexeo

Roundtable 2

September 05, 2025 | 09:45 AM (EDT) - 10:30 AM (EDT)

Arrhythmogenic cardiomyopathy (ACM) is a rare, inherited cardiac disorder associated with ventricular arrhythmias, fibrofatty myocardial replacement, and sudden cardiac death (SCD). Mutations in the plakophilin-2 (PKP2) gene are the most common cause of ACM. Currently, there are no diseasemodifying therapies for PKP2-ACM; standard care focuses on arrhythmia control and SCD prevention through antiarrhythmics, ICDs, and ablation, without addressing the underlying cause.