Event category: Late-Breaking Clinical Trial

This late-breaking clinical trials session showcases novel therapies and technologies advancing the treatment of atrial and ventricular arrhythmias. Presentations include first-in-human and multicenter clinical data on wearable neuromodulation following pulse field ablation, next-generation pulse field ablation techniques, innovative lesion creation strategies for ventricular tachycardia, map-guided redo ablation for persistent atrial fibrillation, and 4D intracardiac echocardiography to support left atrial appendage closure and concomitant ablation procedures. Together, these studies highlight emerging approaches designed to improve procedural precision, safety, and long-term rhythm outcomes in electrophysiology.

This late-breaking clinical trials session highlights emerging innovations that are shaping the future of cardiac rhythm management. Presentations feature first-in-human and early feasibility data on novel pacing technologies, advances in physiologic pacing guided by imaging, next-generation extravascular ICD sensing capabilities, digital solutions to optimize antiarrhythmic drug management, and new insights from the MODULAR ATP trial. Together, these studies showcase cutting-edge research aimed at improving procedural success, expanding access to care, and advancing outcomes for patients with cardiac arrhythmias.